Structurally and Stereochemically Diverse Tetrahydropyran.

The use of iodobenzene diacetate and iodine under photolytic conditions provides and efficient method for the oxidative cyclization of spiroacetals bearing an hydroxyalkyl side chain to bis-spiroacetals. An overview is provided of the use of this reaction for the synthesis of several bis-spiroacetal containing natural products such as the polyether antibiotics salinomycin and CP44,161 and the.

Janus-Faced Aluminum A Demonstration of Unique Lewis Acid and Lewis Base Behavior of the Aluminum Atom in (LAlB(C6F5)3).

David Evans synthesis of the macrolide cytovaricin, considered a classic, utilizes oxazolidinone chiral auixiliaries for one asymmetric alkylation reaction and. PDF evans enolate alkylation-hydrolysisx. Preparation of Enantiomerically enriched Compounds The source of chirality in the oxazolidinone is an amino alcohol, which are essentially amides, the enolates are entirely the Z- isomer (using.

The current book, Chemoinformatics and Computational Chemical Biology, is a successor to Bajorath’s 2004 book Chemoinformatics: concepts, methods, and tools for drug discovery (9). Its chapters cover such a wide range of topics that it is not possible in this introductory article to give a detailed analysis of trends in each of the fields. Instead, some general trends will be highlighted.

Preface Comprehensive Organic Functional Group Transformations (COFGT 1995) presented the vast subject of organic synthesis in terms of the introduction and interconversion of functional groups, according to a rigorous system, designed to cover all known and as yet unknown functional groups.

The synthesis furnished the product in good enantiopurity (96% ee) in eleven synthetic steps starting from commercially available 2-methoxypyridine. The key reactions in this synthesis are Sharpless asymmetric epoxidation and Corey-Stille coupling. Attempts towards a more efficient synthesis of the DE-fragment of (R)-hCPT which were not successful, but led to the synthesis of novel non-lactone.